Cystic fibrosis can involve which organs besides the lungs?

Cystic fibrosis can involve which organs besides the lungs?

• A. Pancreas, liver, kidneys, and intestine
• B. Heart and brain
• C. Muscles and bones
• D. Skin and hair

Answer: (A)

Cystic fibrosis is caused by a CFTR gene mutation that makes thick, sticky secretions block the ducts of several exocrine organs. Because of this, organs with ducts besides the lungs are commonly involved: the pancreas can be obstructed, leading to pancreatic insufficiency and malabsorption; the liver can develop biliary disease from blocked bile ducts; the intestines can experience blockages such as meconium ileus in newborns and distal intestinal obstruction later; and the kidneys can be affected, though this is less common. The other organ groups listed aren’t typical targets of CF as primary nonpulmonary involvement.

Cystic fibrosis is caused by a CFTR gene mutation that makes thick, sticky secretions block the ducts of several exocrine organs. Because of this, organs with ducts besides the lungs are commonly involved: the pancreas can be obstructed, leading to pancreatic insufficiency and malabsorption; the liver can develop biliary disease from blocked bile ducts; the intestines can experience blockages such as meconium ileus in newborns and distal intestinal obstruction later; and the kidneys can be affected, though this is less common. The other organ groups listed aren’t typical targets of CF as primary nonpulmonary involvement.