What type of collagen is formed first in the proliferation stage?

What type of collagen is formed first in the proliferation stage?

• A. Type 3
• B. Type 1
• C. Type 2
• D. Type 4

Answer: (A)

The question is testing which collagen type appears first when the wound enters the proliferative phase. In this stage, fibroblasts lay down a provisional extracellular matrix to form granulation tissue. The initial collagen produced is type III, which creates a loose, flexible scaffold that supports new tissue and blood vessels. Over time, this early matrix is replaced by type I collagen during remodeling, which strengthens the scar. So the earliest collagen in the proliferative phase is type III. Type I becomes dominant later, type II is associated with cartilage, and type IV is a basement membrane collagen not the provisional matrix in wound healing.

The question is testing which collagen type appears first when the wound enters the proliferative phase. In this stage, fibroblasts lay down a provisional extracellular matrix to form granulation tissue. The initial collagen produced is type III, which creates a loose, flexible scaffold that supports new tissue and blood vessels. Over time, this early matrix is replaced by type I collagen during remodeling, which strengthens the scar. So the earliest collagen in the proliferative phase is type III. Type I becomes dominant later, type II is associated with cartilage, and type IV is a basement membrane collagen not the provisional matrix in wound healing.