Which phase is primarily concerned with capillary formation and collagen synthesis?

Which phase is primarily concerned with capillary formation and collagen synthesis?

• A. Proliferation
• B. Hemostasis
• C. Epithelization
• D. Remodeling

Answer: (A)

During the proliferation phase, the wound is rebuilt with new tissue. Key processes include angiogenesis, where new capillaries grow into the wound to supply oxygen and nutrients, and fibroblast-driven collagen synthesis to form the extracellular matrix. This creates granulation tissue that supports epithelial cells as they migrate to re-cover the surface. While epithelialization also occurs during this time, the hallmark features driving tissue formation are the capillary network and collagen deposition. Remodeling happens later, reorganizing and strengthening the collagen with decreased vascularity.

During the proliferation phase, the wound is rebuilt with new tissue. Key processes include angiogenesis, where new capillaries grow into the wound to supply oxygen and nutrients, and fibroblast-driven collagen synthesis to form the extracellular matrix. This creates granulation tissue that supports epithelial cells as they migrate to re-cover the surface. While epithelialization also occurs during this time, the hallmark features driving tissue formation are the capillary network and collagen deposition. Remodeling happens later, reorganizing and strengthening the collagen with decreased vascularity.